G-6-P dehydrogenase deficiency is associated with heamolysis of :

Options

A. Leucocytes
B. Lymphocytes
C. Platelets
D. RBCs

Answer

### Step-by-Step Solution:

1. **Understanding the Question**: The question asks about the association of G-6-P dehydrogenase deficiency with hemolysis. Hemolysis refers to the destruction of red blood cells (RBCs).

2. **Identifying G-6-P Dehydrogenase**: Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that plays a crucial role in the pentose phosphate pathway, which is important for maintaining the health of red blood cells by protecting them from oxidative damage.

3. **Effects of G6PD Deficiency**: When there is a deficiency of G6PD, the red blood cells become more susceptible to oxidative stress. This can lead to the damage and premature destruction of RBCs, a condition known as hemolysis.

4. **Evaluating the Options**:
- **Leukocytes**: These are white blood cells involved in immune responses. They are not primarily affected by G6PD deficiency.
- **Lymphocytes**: A type of leukocyte, also involved in immune functions. They do not undergo hemolysis due to G6PD deficiency.
- **Platelets**: These are involved in blood clotting and are not affected by G6PD deficiency.
- **RBC (Red Blood Cells)**: These are directly affected by G6PD deficiency, leading to hemolysis.

5. **Conclusion**: The correct answer is that G-6-P dehydrogenase deficiency is associated with hemolysis of **RBCs**.