Interference in development and maturation of RBC is caused by

Options

A. Hg pollution
B. Pb pollution
C. S pollution
D. All of these

Answer

To answer the question regarding the interference in the development and maturation of red blood cells (RBCs), we will analyze the potential pollutants listed in the options: Hg (mercury), Pb (lead), S (sulfur), and determine which one is responsible.

### Step-by-Step Solution:

1. **Understanding RBC Development**:
- Red blood cells (RBCs) are formed through a process called erythropoiesis, which involves the maturation of erythropoietic stem cells into mature RBCs.

2. **Identifying the Pollutants**:
- The options given are:
- Hg pollution (mercury)
- Pb pollution (lead)
- S pollution (sulfur)
- All of these

3. **Analyzing Mercury (Hg)**:
- Mercury is a toxic heavy metal that can cause various metabolic disorders and neurological syndromes (e.g., Minamata disease). However, there is no direct evidence that mercury specifically interferes with the development and maturation of RBCs.

4. **Analyzing Lead (Pb)**:
- Lead is also a toxic heavy metal. It is known to interfere with heme synthesis, which is crucial for the formation of hemoglobin in RBCs. Lead inhibits several key enzymes involved in heme synthesis, leading to hematological damage and affecting the maturation of RBCs.

5. **Analyzing Sulfur (S)**:
- Sulfur is a non-metal that is essential for the body and is found in amino acids. While it plays a role in protein synthesis, there is no evidence to suggest that sulfur pollution directly interferes with the development of RBCs.

6. **Conclusion**:
- Based on the analysis, lead (Pb) pollution is the primary pollutant that interferes with the development and maturation of RBCs. Therefore, the correct answer is **Pb pollution**.

### Final Answer:
The interference in the development and maturation of RBCs is caused by **Pb pollution (lead)**.

---