Which of the following phenomena leads to variation in DNA ?

Options

A. Linkage, mutation
B. Recombination, linkage
C. Mutation, recombination
D. Aneuploidy, linkage

Answer

To answer the question "Which of the following phenomena leads to variation in DNA?", we can break down the solution into the following steps:

### Step-by-Step Solution:

1. **Understanding DNA Structure**:
- DNA is composed of nucleotide sequences, which are made up of nitrogenous bases. The arrangement of these bases is crucial for genetic information.

2. **Defining Variation**:
- Variation in DNA refers to changes in the nucleotide sequences. These changes can occur due to different phenomena.

3. **Identifying Key Phenomena**:
- Two primary phenomena that lead to variation in DNA are **mutation** and **recombination**.

4. **Explaining Mutation**:
- Mutation is a sudden change in the nucleotide sequence. This can involve:
- Deletion of nucleotides,
- Addition of new nucleotides,
- Substitution, where one nucleotide is replaced by another.

5. **Explaining Recombination**:
- Recombination occurs during gamete formation. It involves the rearrangement of genetic material, leading to variations in the nucleotide sequences in the resulting gametes.

6. **Conclusion**:
- Both mutation and recombination are responsible for variations in DNA. Therefore, the correct answer to the question is that these two phenomena lead to variation in DNA.

### Final Answer:
The phenomena that lead to variation in DNA are **mutation** and **recombination**.

---