In which of the following disorder gynacomastia symptom is seen in individuals ?

Options

A. Down's syndrome
B. Turner's syndrome
C. Klinefelter's syndrome
D. Phenylketonuria

Answer

**Step-by-Step Solution:**

1. **Understanding Gynecomastia**: Gynecomastia is defined as the abnormal enlargement of breast tissue in males. It is important to recognize that this condition is not typical and is often associated with certain disorders.

2. **Identifying the Disorders**: The question asks which disorder is associated with gynecomastia. The options provided include Klinefelter's syndrome, Down syndrome, Turner syndrome, and Phenylketonuria.

3. **Analyzing Each Disorder**:
- **Klinefelter's Syndrome**: This condition is characterized by the presence of an extra X chromosome in males (47, XXY). Individuals with this syndrome often exhibit gynecomastia due to hormonal imbalances.
- **Down Syndrome**: This is caused by trisomy of chromosome 21 and does not typically present with gynecomastia.
- **Turner Syndrome**: This syndrome involves the absence of one X chromosome (45, X) in females and does not result in gynecomastia.
- **Phenylketonuria (PKU)**: This is a metabolic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase and is unrelated to breast tissue development.

4. **Conclusion**: Based on the analysis, Klinefelter's syndrome is the only disorder listed that is associated with the symptom of gynecomastia. Therefore, the correct answer is Klinefelter's syndrome.

5. **Final Answer**: Klinefelter's syndrome is the disorder in which gynecomastia symptoms are seen in individuals.

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