Which of the following is not a hereditary disease

Options

A. Cretinism
B. Cystic fibrosis
C. Thalassaemia
D. Haemophilia

Answer

To determine which of the following is not a hereditary disease, we need to analyze each option provided:

1. **Cretinism**:
- Cretinism, also known as congenital iodine deficiency syndrome, is a condition that arises due to a deficiency of thyroid hormones at birth.
- It is classified as a congenital disorder, meaning it is present at birth, but it is not inherited from parents to offspring.
- Therefore, it is considered a non-hereditary disease.

2. **Cystic Fibrosis**:
- Cystic fibrosis is an autosomal recessive disorder caused by mutations in the CFTR gene.
- This means that it is inherited and passed down from parents to children.
- Thus, it is a hereditary disease.

3. **Thalassemia**:
- Thalassemia is also an autosomal recessive disorder characterized by reduced production of hemoglobin and red blood cells.
- Like cystic fibrosis, it is inherited from parents to offspring, making it a hereditary disease.

4. **Hemophilia**:
- Hemophilia is an X-linked recessive disorder that affects blood clotting.
- It is inherited and can be passed from parents to children, thus it is also a hereditary disease.

After analyzing all the options, we conclude that the only non-hereditary disease among the options is **Cretinism**.

### Final Answer:
**Cretinism is not a hereditary disease.**