A : Sickel cell anemia occurs due to the point mutation.
R : mRNA produced from `Hb(s)` gene has GAG instead of GUG.

Options

A. If both Assertion & Reason are true and the reason is the correct explanation of the assertion, then mark (1)
B. If both Assertion & Reason are true and the reason is not the correct explanation of the assertion , then mark (2)
C. If Assertion is true statement but Reason is false, then mark (3)
D. If both Assertion and Reason are false statements, then mark (4)

Answer

To solve the assertion-reason question regarding sickle cell anemia, we will analyze both the assertion and the reason step by step.

### Step 1: Understand the Assertion
The assertion states that "Sickle cell anemia occurs due to point mutation."

- **Explanation**: Sickle cell anemia is indeed caused by a point mutation in the gene that encodes for the beta-globin subunit of hemoglobin. This mutation leads to the production of abnormal hemoglobin (HbS) which causes red blood cells to become sickle-shaped.

**Hint**: Recall that a point mutation involves a change in a single nucleotide in the DNA sequence.

### Step 2: Understand the Reason
The reason states that "mRNA produced from the Hb(s) gene has GAG instead of GUG."

- **Explanation**: The correct information is that in sickle cell anemia, the mutation changes the DNA sequence from GAG (which codes for glutamic acid in normal hemoglobin) to GTG (which codes for valine in sickle hemoglobin). Therefore, the mRNA produced from the sickle cell gene would have GUG, not GAG.

**Hint**: Remember that the mRNA sequence is derived from the DNA template, and the codons for amino acids can change due to mutations.

### Step 3: Evaluate the Assertion and Reason
Now, we need to evaluate the truth of both the assertion and the reason:

- The assertion is **true**: Sickle cell anemia is caused by a point mutation.
- The reason is **false**: The mRNA produced from the sickle cell hemoglobin gene has GUG instead of GAG.

### Step 4: Conclusion
Based on the evaluation:
- The assertion is true, but the reason is false.

Thus, the correct answer is that the assertion is true and the reason is false.

**Final Answer**: Assertion is true, Reason is false.