Drugs such as Thalidomide taken by woman in first trimester of pregnancy cause all the following malformations in the developing embryo except

Options

A. Phocomelia
B. Amelia
C. Heart disorder
D. Placentitis

Answer

To solve the question regarding the malformations caused by Thalidomide taken during the first trimester of pregnancy, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Context**: Recognize that Thalidomide is a drug known to cause teratogenic effects when taken during pregnancy, particularly in the first trimester when the embryo is developing.

**Hint**: Teratogens are substances that can cause developmental malformations in embryos.

2. **Identify Common Malformations**: Research the known malformations associated with Thalidomide. These include:
- **Phocomelia**: A condition where limbs are abnormally short.
- **Amelia**: The absence of one or more limbs.
- **Heart disorders**: Various congenital heart defects can occur.

**Hint**: Focus on the specific malformations that are documented in medical literature related to Thalidomide.

3. **Examine the Exception**: The question asks for the malformation that is NOT caused by Thalidomide. Among the options provided, we need to identify which one does not belong to the list of known effects.

**Hint**: Look for a term that is not commonly associated with the effects of Thalidomide.

4. **Identify the Correct Answer**: Based on the information provided, **Placentitis** (inflammation of the placenta) is not associated with Thalidomide. Therefore, it is the correct answer to the question.

**Hint**: Compare the terms and remember that some conditions may sound similar but are not related to the drug's effects.

### Final Answer:
The malformation that is NOT caused by Thalidomide is **Placentitis**.