Which property of genetic code is utilised in wobble hypothesis ?

Options

A. Degeneracy
B. Non-overlapping
C. Non-ambiguous
D. Universal

Answer

### Step-by-Step Solution:

1. **Understanding the Genetic Code**: The genetic code consists of triplet codons, which are sequences of three nucleotides that correspond to specific amino acids. Each codon can be read to determine which amino acid will be added during protein synthesis.

2. **Identifying Properties of the Genetic Code**: The genetic code has several important properties, including:
- It is triplet in nature.
- It has start and stop signals (e.g., AUG is the start codon, and UAA, UAG, UGA are stop codons).
- It is universal across organisms.
- It is non-ambiguous (each codon specifies only one amino acid, with a few exceptions).
- It is comma-less and read in a specific direction (5' to 3').
- It is non-overlapping.
- It exhibits degeneracy.

3. **Explaining Degeneracy**: Degeneracy refers to the phenomenon where multiple codons can code for the same amino acid. For example, the amino acid phenylalanine can be coded by UUU and UUC. The first two bases of these codons are identical, while the third base differs.

4. **Introducing the Wobble Hypothesis**: The wobble hypothesis, proposed by Francis Crick in 1966, explains how the degeneracy of the genetic code allows for flexibility in base pairing at the third position of the codon. This means that the first two bases must be complementary to the corresponding bases in the tRNA, while the third base can vary without affecting the amino acid being coded.

5. **Conclusion**: The property of the genetic code that is utilized in the wobble hypothesis is **degeneracy**. This allows for the same amino acid to be specified by multiple codons, particularly differing at the third nucleotide position.

### Final Answer:
The property of the genetic code utilized in the wobble hypothesis is **degeneracy**.