Activation of amino acids during translation is done by

Options

A. Peptidyl transferase
B. Aminoacyl - tRNA synthetase
C. Methionine
D. Initiation factors

Answer

### Step-by-Step Solution

1. **Understanding the Question**: The question asks about the enzyme responsible for the activation of amino acids during translation.

2. **Defining Activation of Amino Acids**: Activation of amino acids refers to the process where an amino acid is attached to its corresponding transfer RNA (tRNA). This is a crucial step in translation, as it prepares the amino acid for incorporation into a growing polypeptide chain.

3. **Identifying the Enzymes**: The options provided include:
- Peptidyl transferase
- Aminoacyl tRNA synthetase
- Methionine
- Initiation factor

4. **Analyzing Each Option**:
- **Peptidyl transferase**: This enzyme is involved in forming peptide bonds between amino acids during translation, not in the activation process.
- **Aminoacyl tRNA synthetase**: This enzyme catalyzes the attachment of an amino acid to its corresponding tRNA, thus activating the amino acid for translation.
- **Methionine**: This is an amino acid and not an enzyme.
- **Initiation factor**: These are proteins that assist in the initiation of translation but do not activate amino acids.

5. **Conclusion**: The enzyme responsible for the activation of amino acids during translation is **aminoacyl tRNA synthetase**.

### Final Answer
The activation of amino acids during translation is done by **aminoacyl tRNA synthetase**.

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