During DNA replication which of the following does not act as substrates?

Options

A. dATP
B. dCTP
C. dUTP
D. dGTP

Answer

**Step-by-Step Solution:**

1. **Understanding DNA Replication**: DNA replication is the process by which a cell makes an exact copy of its DNA. This occurs in the cytoplasm for prokaryotes and in the nucleus for eukaryotes.

2. **Identifying Substrates**: During DNA replication, specific molecules known as deoxyribonucleoside triphosphates (dNTPs) serve as substrates. These include:
- dATP (deoxyadenosine triphosphate)
- dCTP (deoxycytidine triphosphate)
- dGTP (deoxyguanosine triphosphate)
- dTTP (deoxythymidine triphosphate)

3. **Analyzing the Given Options**: The options provided are:
- dATP
- dCTP
- dUTP
- dGTP

4. **Identifying the Non-Substrate**: Among these options, dATP, dCTP, and dGTP are all deoxyribonucleoside triphosphates that are used in DNA synthesis. However, dUTP (deoxyuridine triphosphate) contains uridine, which is not found in DNA; uridine is a component of RNA.

5. **Conclusion**: Therefore, the molecule that does not act as a substrate during DNA replication is **dUTP**.

**Final Answer**: dUTP (Option C)

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