Select the correct one (w.r.t. Wobble hypothesis)

Options

A. Third base of a codon lacks vibrating capacity
B. Third base can establish H-bonds even with the non complementary anticodon
C. Specificity of a anticodon is particulary determined by first two codon
D. Major cause of degeneracy is the first two N-bases of codon

Answer

### Step-by-Step Solution:

1. **Understanding the Wobble Hypothesis**:
The Wobble Hypothesis explains how the third base of a codon can pair with more than one type of base in the corresponding anticodon. This flexibility allows for a degree of redundancy in the genetic code.

2. **Analyzing Each Option**:
- **Option 1**: "Third base of the codon lacks vibrating capacity."
- This statement is incorrect. The third base does have wobble capacity, meaning it can pair with non-complementary bases.

- **Option 2**: "Third base can establish hydrogen bond even with non-complementary anticodon."
- This statement is correct. The third base can indeed form hydrogen bonds with non-complementary bases, which is a key aspect of the Wobble Hypothesis.

- **Option 3**: "Specificity of an anticodon is particularly determined by the first two codons."
- This statement is incorrect. The specificity of an anticodon is primarily determined by the first base pairing, while the third base can vary.

- **Option 4**: "Major cause of the degeneracy is the first two nitrogen bases of the codon."
- This statement is also incorrect. The degeneracy of the genetic code is largely due to variations in the third base of the codon.

3. **Conclusion**:
After analyzing all the options, the correct statement with respect to the Wobble Hypothesis is **Option 2**: "Third base can establish hydrogen bond even with non-complementary anticodon."