Majority of unusual bases are found in tRNA, T `psi` C loop is

Options

A. First loop from 5-end of tRNA
B. AA-tRNA sythetase binding loop
C. Ribsomal binding loop
D. Nodoc site

Answer

To solve the question regarding the T ψ C loop in tRNA and its association with unusual bases, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding tRNA Structure**:
- Transfer RNA (tRNA) is a molecule that helps in the translation of mRNA into proteins. It typically consists of 73 to 93 nucleotides and has a characteristic cloverleaf structure in 2D and an L-shaped structure in 3D.

**Hint**: Recall the general structure of tRNA and its role in protein synthesis.

2. **Identifying the Loops in tRNA**:
- tRNA contains several important loops: the D loop, the anticodon loop, the T ψ C loop, and the acceptor stem. Each of these loops has specific functions and characteristics.

**Hint**: Familiarize yourself with the different loops in tRNA and their respective roles.

3. **Focusing on the T ψ C Loop**:
- The T ψ C loop is specifically known for containing unusual bases such as ribothymidine (T) and pseudouridine (ψ). These bases contribute to the stability and function of tRNA.

**Hint**: Remember the significance of unusual bases in tRNA and where they are typically located.

4. **Analyzing the Options Given**:
- The question provides four options regarding the T ψ C loop:
- A) 1st loop from 5' end of tRNA
- B) AA tRNA synthetase binding loop
- C) Ribosomal binding loop
- D) NODOC site

**Hint**: Evaluate each option based on your understanding of tRNA structure and function.

5. **Determining the Correct Answer**:
- The T ψ C loop is not the first loop from the 5' end, nor is it the AA tRNA synthetase binding loop or the NODOC site. The correct association for the T ψ C loop is that it plays a role in binding with the ribosome, which makes option C (Ribosomal binding loop) the correct answer.

**Hint**: Consider the functional roles of each loop and how they relate to the overall process of translation.

6. **Conclusion**:
- Therefore, the T ψ C loop is associated with the ribosomal binding loop, where unusual bases are found, making option C the right choice.

### Final Answer:
The T ψ C loop is associated with the ribosomal binding loop in tRNA.