In general, the order of hydrolysis among acid derivatives is

Options

A. `RCOClgtRCONH_(2)gtRCOOR'gt(RCO)_(2)O`
B. `RCOClgt(RCO)_(2)OgtRCOOR'gtRCONH_(2)`
C. `(RCO)_(2)OgtRCOClgtRCONH_(2)gtRCOOR'`
D. `RCOOR'gtRCOClgt(RCO)_(2)OgtRCONH_(2)`

Answer

To determine the order of hydrolysis among acid derivatives, we will analyze the reactivity of each type of acid derivative based on their structure and the effects of substituents.

### Step-by-Step Solution:

1. **Identify the Acid Derivatives**:
- Acyl Chloride (RCOCl)
- Anhydride (RCOOR')
- Ester (RCOOR)
- Amide (RCONH2)

2. **Analyze the Electrophilicity**:
- **Acyl Chloride**: The presence of chlorine (a good leaving group) increases the electrophilicity of the carbonyl carbon, making it highly reactive towards nucleophiles.
- **Anhydride**: Anhydrides have two carbonyl groups, and the electron-withdrawing nature of the carbonyl increases the electrophilicity, making them reactive but less so than acyl chlorides.
- **Ester**: Esters have an alkoxy group (OR) which donates electron density through +I effect, reducing the electrophilicity of the carbonyl carbon, thus they are less reactive than anhydrides.
- **Amide**: Amides have a nitrogen atom with a lone pair that can participate in resonance with the carbonyl, which significantly decreases the electrophilicity of the carbonyl carbon, making amides the least reactive among these derivatives.

3. **Rank the Reactivity**:
- Based on the above analysis, we can rank the reactivity of the acid derivatives in terms of their hydrolysis:
- **Most Reactive**: Acyl Chloride (RCOCl)
- **Next**: Anhydride (RCOOR')
- **Then**: Ester (RCOOR)
- **Least Reactive**: Amide (RCONH2)

4. **Final Order of Hydrolysis**:
- The order of hydrolysis among the acid derivatives is:
1. Acyl Chloride (most reactive)
2. Anhydride
3. Ester
4. Amide (least reactive)

### Final Answer:
The order of hydrolysis among acid derivatives is:
**Acyl Chloride > Anhydride > Ester > Amide**

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