Asqirin is obtained by the reaction of salicylic acid with

Options

A. Acetic anhydride
B. Acetaldehyde
C. Acetyl chloride
D. Methanol

Answer

To determine the correct reactant for the formation of aspirin from salicylic acid, we can follow these steps:

### Step 1: Identify the Reactants
We know that aspirin (acetylsalicylic acid) is synthesized from salicylic acid. The options given for the reactants are:
- Acetic anhydride
- Acetyl aldehyde
- Acetyl chloride
- Methanol

### Step 2: Understand the Structure of Salicylic Acid
Salicylic acid has a hydroxyl group (-OH) attached to a benzene ring and a carboxylic acid group (-COOH). Its structure is crucial for the reaction.

### Step 3: Identify the Structure of Aspirin
Aspirin is formed by the acetylation of the hydroxyl group of salicylic acid. This means that we need a reagent that can introduce an acetyl group (-COCH3) to the -OH group of salicylic acid.

### Step 4: Analyze the Options
- **Acetic Anhydride**: This compound can provide the acetyl group needed for the reaction with salicylic acid, leading to the formation of aspirin.
- **Acetyl Aldehyde**: This is not typically used for the acetylation of phenolic compounds.
- **Acetyl Chloride**: While it can also introduce an acetyl group, it is less commonly used than acetic anhydride for this specific reaction.
- **Methanol**: This is an alcohol and does not provide an acetyl group.

### Step 5: Conclusion
The most suitable reactant for the synthesis of aspirin from salicylic acid is **acetic anhydride**. This is because it effectively reacts with the hydroxyl group of salicylic acid to form aspirin through an acetylation reaction.

### Final Answer
Aspirin is obtained by the reaction of salicylic acid with **acetic anhydride**.

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