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The most reactive compound towards Hofma...

The most reactive compound towards Hofmann bromamide degradation is

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To determine the most reactive compound towards the Hofmann bromamide degradation reaction, we need to analyze the given options based on the presence of electron-withdrawing or electron-donating groups attached to the amide. ### Step-by-Step Solution: 1. **Understanding the Hofmann Bromamide Degradation Reaction**: - The Hofmann bromamide degradation reaction involves the conversion of an amide to a primary amine with the loss of one carbon atom. The reaction is typically carried out using bromine (Br2) in the presence of a strong base like KOH or NaOH. 2. **Identifying the Role of Substituents**: - The reactivity of the amide in the Hofmann degradation reaction is influenced by the substituents attached to the amide nitrogen. Electron-withdrawing groups (EWGs) increase the reactivity by stabilizing the negative charge that forms during the reaction, while electron-donating groups (EDGs) decrease the reactivity. 3. **Analyzing the Given Options**: - Let's consider the four compounds provided in the options: 1. **Compound with NO2 group**: This is a strong electron-withdrawing group (EWG) due to its -I (inductive) and -M (mesomeric) effects. 2. **Compound with OCH3 group**: This is an electron-donating group (EDG) due to its +I and +M effects, which decreases reactivity. 3. **Compound with CH3 group**: This is also an EDG, which similarly decreases reactivity. 4. **Compound with Cl group**: Chlorine is an electron-withdrawing group due to its -I effect, but it is less effective than NO2. 4. **Determining the Most Reactive Compound**: - Among the given options, the compound with the **NO2 group** is the most reactive towards the Hofmann bromamide degradation reaction. This is because it significantly enhances the acidity of the amide hydrogen, facilitating the initial step of the reaction. 5. **Conclusion**: - Therefore, the most reactive compound towards Hofmann bromamide degradation is the one containing the **NO2 group**. ### Final Answer: The most reactive compound towards Hofmann bromamide degradation is the compound with the **NO2 group**.
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