Select the disease caused by both hyposecretion as well hypersecretion of a hormone

Options

A. Dwarfism
B. Goitre
C. Acromegaly
D. Diabetes insipidus

Answer

To solve the question of which disease is caused by both hyposecretion and hypersecretion of a hormone, let's analyze each option step by step:

### Step 1: Understand the Terms
- **Hyposecretion** refers to the underproduction of a hormone.
- **Hypersecretion** refers to the overproduction of a hormone.

### Step 2: Analyze Each Option

#### Option A: Dwarfism
- Dwarfism is primarily caused by the **hyposecretion** of growth hormone from the pituitary gland. There is no involvement of hypersecretion in this condition.
- **Conclusion**: This option is incorrect.

#### Option B: Goiter
- Goiter is characterized by the enlargement of the thyroid gland. It can be caused by:
- **Hyposecretion** of thyroid hormones (leading to a condition called hypothyroidism).
- **Hypersecretion** of thyroid hormones (leading to a condition called hyperthyroidism).
- Both conditions can result in goiter due to altered metabolism of thyroid hormones.
- **Conclusion**: This option is correct.

#### Option C: Acromegaly
- Acromegaly is caused by the **hypersecretion** of growth hormone, leading to enlarged extremities and features. There is no involvement of hyposecretion in this condition.
- **Conclusion**: This option is incorrect.

#### Option D: Diabetes Insipidus
- Diabetes insipidus is primarily caused by the **hyposecretion** of vasopressin (antidiuretic hormone) from the pituitary gland, leading to excessive urination and thirst. There is no involvement of hypersecretion in this condition.
- **Conclusion**: This option is incorrect.

### Step 3: Final Answer
Based on the analysis, the disease caused by both hyposecretion and hypersecretion of a hormone is **Goiter**.