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Which of the following explains Haldane ...

Which of the following explains Haldane effect?

A

Bicarbonate ions diffuse out from RBCs into plasma, whereas chloride ions move from the plasma into RBCs

B

Excess of 2,3 diphosphoglycerate dissociates oxygen from haemoglobin

C

As carbon dioxide enters the systemic blood stream, it causes more oxygen to dissociate from haemoglobin

D

Combination of oxygen with haemoglobin causes the haemoglobin to become a stronger acid

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