choose the correct option w.r.t. phases of mitosis

Options

A. prophase shows disappearance of organelles
B. metaphase is the best stage to study chromosomes
C. anaphase shows spllitting of chromosomes
D. In interphase , cell show least metabolism since it is the resting stage

Answer

To solve the question regarding the phases of mitosis, we will analyze each statement provided in the options and determine their validity based on our understanding of mitosis.

### Step-by-Step Solution:

1. **Understanding Mitosis**: Mitosis is a type of cell division that results in two daughter cells, each having the same number of chromosomes as the parent cell. It consists of several phases: prophase, metaphase, anaphase, and telophase.

2. **Analyzing the Options**:
- **Option 1**: "Prophase shows disappearance of organelles."
- This statement is **correct**. During prophase, the nuclear material condenses, and organelles begin to disappear as the cell prepares for division.

- **Option 2**: "Metaphase is the best stage to study chromosomes."
- This statement is also **correct**. In metaphase, chromosomes are maximally condensed and aligned at the equatorial plate, making them easier to observe under a microscope.

- **Option 3**: "Anaphase shows splitting of chromosomes."
- This statement is **correct**. During anaphase, the centromeres split, and the sister chromatids are pulled apart to opposite poles of the cell.

- **Option 4**: "In the interphase, the cell shows least metabolism."
- This statement is **incorrect**. Interphase is a highly active phase where the cell undergoes growth, DNA replication, and synthesis of proteins, indicating high metabolic activity.

3. **Conclusion**: The correct option regarding the phases of mitosis is **Option 4**, which incorrectly states that interphase shows the least metabolism.

### Final Answer:
**Option 4** is the correct answer.