In which of the following stage does the centromere splitting takes place

Options

A. Anaphase-I
B. Anaphase-II
C. Telophase-I
D. Metaphase-I

Answer

To determine in which stage the centromere splitting occurs during meiosis, we need to analyze the stages of meiosis and understand the role of the centromere.

### Step-by-Step Solution:

1. **Understanding Meiosis**: Meiosis is a type of cell division that reduces the chromosome number by half and consists of two main stages: Meiosis I and Meiosis II.

2. **Stages of Meiosis I**:
- **Prophase I**: Homologous chromosomes pair up and exchange genetic material (crossing over).
- **Metaphase I**: Homologous pairs align at the metaphase plate.
- **Anaphase I**: Homologous chromosomes are pulled apart to opposite poles, but the centromeres do not split. Each chromosome still consists of two sister chromatids.
- **Telophase I**: The cell divides into two haploid cells, but the sister chromatids remain attached.

3. **Stages of Meiosis II**:
- **Prophase II**: Chromosomes condense again in the two haploid cells.
- **Metaphase II**: Chromosomes align at the metaphase plate.
- **Anaphase II**: This is the critical stage where the centromeres split, allowing the sister chromatids to separate and move towards opposite poles.
- **Telophase II**: The cells divide again, resulting in four haploid cells.

4. **Conclusion**: The centromere splitting occurs specifically during **Anaphase II** of meiosis. This is the stage where sister chromatids are separated, leading to the formation of individual chromosomes in the daughter cells.

### Final Answer:
The centromere splitting takes place in **Anaphase II** of meiosis.

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