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which of the following is important for conversion of pepsinogens into pepsin?
1) F e 2 +
2) HCL
3) Bicarbonate ions
4) Enterokinase

A

`Fe^(2+)`

B

HCL

C

Bicarbonate ions

D

Enterokinase

Text Solution

AI Generated Solution

The correct Answer is:
To solve the question regarding which substance is important for the conversion of pepsinogens into pepsin, we can follow these steps: ### Step-by-Step Solution: 1. **Understanding Pepsinogen and Pepsin**: - Pepsinogen is an inactive precursor (zymogen) of the enzyme pepsin, which is involved in protein digestion. - Pepsin is the active form that breaks down proteins into smaller peptides. 2. **Location of Conversion**: - The conversion of pepsinogen to pepsin occurs in the stomach, where pepsinogen is secreted by the gastric chief cells. 3. **Role of Hydrochloric Acid (HCl)**: - Hydrochloric acid (HCl) is secreted by the parietal cells in the stomach and creates an acidic environment. - The acidic pH is crucial for the activation of pepsinogen. When pepsinogen comes into contact with HCl, it undergoes a conformational change and is converted into the active enzyme pepsin. 4. **Evaluating Other Options**: - **Fe²⁺ (Iron ions)**: While iron is important for various biological processes, it is not directly involved in the conversion of pepsinogen to pepsin. - **Bicarbonate ions**: These are typically involved in neutralizing stomach acid in the intestines, not in the activation of pepsinogen. - **Enterokinase**: This enzyme activates trypsinogen to trypsin in the small intestine, but it does not play a role in the conversion of pepsinogen to pepsin. 5. **Conclusion**: - The substance that is important for the conversion of pepsinogens into pepsin is **HCl (Hydrochloric Acid)**. ### Final Answer: The correct answer is **2) HCl**. ---
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