Which of the following is a correct match between hormone, its source gland and the disorder caused due to its over secretion.

Options

A. Oxytocin (Hormone) Pars intermedia (Source gland) Addison's disease (Disorder)
B. Thyroxine (Hormone) Thyroid gland (Source gland) Grave's disease (Disorder)
C. TSH (Hormone) Pars distalis (Source gland) Guli's disease (Disorder)
D. Calcitonin (Hormone) Thyroid gland (Source gland) Cretinism (Disorder)

Answer

To solve the question regarding the correct match between a hormone, its source gland, and the disorder caused by its over secretion, we will analyze each option provided in the question step by step.

### Step 1: Understand the Question
The question asks for a correct match between a hormone, its source gland, and the disorder that results from the over secretion of that hormone. We need to identify the correct pairings.

### Step 2: Analyze Each Option
1. **Oxytocin**:
- **Source Gland**: Pars intermedia (middle pituitary)
- **Disorder**: Not specified but we need to check if it causes any disorder due to over secretion.
- **Analysis**: Oxytocin is actually synthesized in the hypothalamus and secreted from the posterior pituitary (pars nervosa), not the pars intermedia. Therefore, this is an incorrect match.

2. **Thyroxine**:
- **Source Gland**: Thyroid gland
- **Disorder**: Graves' disease
- **Analysis**: This is a correct match. Over secretion of thyroxine leads to Graves' disease, which is characterized by symptoms such as thyroid enlargement, increased heart rate, and weight loss.

3. **TSH (Thyroid Stimulating Hormone)**:
- **Source Gland**: Anterior pituitary (pars distalis)
- **Disorder**: Given as Gullies disease
- **Analysis**: While TSH is correctly sourced from the anterior pituitary, it does not cause Gullies disease due to hyper secretion. This is an incorrect match.

4. **Calcitonin**:
- **Source Gland**: Thyroid gland
- **Disorder**: Cretinism
- **Analysis**: Calcitonin is indeed secreted from the thyroid gland, but cretinism is caused by the hyposecretion of thyroxine, not calcitonin. Therefore, this is also an incorrect match.

### Step 3: Conclusion
After analyzing all options, the only correct match is:
- **Thyroxine** from the **Thyroid gland** causing **Graves' disease** due to over secretion.

Thus, the correct answer is the second option.