Which of the following is not true w.r.t. HIV?

Options

A. Reverse transcription results in production of a double stranded DNA copy of the viral genome
B. ELISA is used as a confirmatory test to determine if a person is infected with HIV.
C. It is a retrovirus
D. It belongs to genus Lentivirus.

Answer

To determine which statement is not true with respect to HIV, we will analyze each option provided in the question step by step.

### Step 1: Analyze the first option
**Statement:** Reverse transcription results in the production of a double-stranded DNA copy of the viral genome.

**Analysis:**
HIV has an RNA genome. The enzyme reverse transcriptase, which is present in HIV, converts this RNA into double-stranded DNA. This process is a key characteristic of retroviruses like HIV. Therefore, this statement is **true**.

### Step 2: Analyze the second option
**Statement:** ELISA is used as a confirmatory test to determine if a person is infected with HIV.

**Analysis:**
ELISA (Enzyme-Linked Immunosorbent Assay) is a screening test used to detect antibodies against HIV in a person's blood. However, it is not a confirmatory test. If ELISA results are positive, a more specific confirmatory test, such as the Western blot test, is performed. Therefore, this statement is **not true**.

### Step 3: Analyze the third option
**Statement:** It is a retrovirus.

**Analysis:**
HIV is classified as a retrovirus because it contains the enzyme reverse transcriptase and replicates its RNA genome through a DNA intermediate. This statement is **true**.

### Step 4: Analyze the fourth option
**Statement:** It belongs to the lentivirus family.

**Analysis:**
HIV is indeed a member of the lentivirus family, which is a subgroup of retroviruses. Other members include the Simian Immunodeficiency Virus (SIV) and Equine Infectious Anemia Virus (EIAV). This statement is also **true**.

### Conclusion
After analyzing all the options, the statement that is **not true** with respect to HIV is the second option: "ELISA is used as a confirmatory test to determine if a person is infected with HIV."

### Final Answer:
**The answer is option B: ELISA is used as a confirmatory test to determine if a person is infected with HIV.**

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