Introduction of ADA gene into bone marrow cells at embryonic stages may act as a permanent cure is which of the following disease ?

Options

A. Thalassemia
B. AIDS
C. SCID
D. Haemophilia

Answer

To determine which disease can be permanently cured by the introduction of the ADA gene into bone marrow cells at embryonic stages, we need to analyze each of the given options:

1. **Thalassemia**:
- Thalassemia is an inherited blood disorder caused by mutations in the genes responsible for hemoglobin production. It results in the formation of abnormal hemoglobin and leads to the destruction of red blood cells and anemia.
- **Conclusion**: Thalassemia is not related to the ADA gene and thus is not the correct answer.

2. **AIDS**:
- AIDS (Acquired Immunodeficiency Syndrome) is caused by the human immunodeficiency virus (HIV). It is not a genetic disorder but rather an infectious one.
- **Conclusion**: Since AIDS is caused by a virus and not by a genetic mutation related to the ADA gene, this option is also incorrect.

3. **SCID (Severe Combined Immunodeficiency)**:
- SCID is a genetic disorder characterized by the absence or dysfunction of T and B lymphocytes, which are crucial for the immune response. This condition is often due to mutations in the gene coding for adenosine deaminase (ADA), which is essential for the breakdown of toxic metabolites in lymphocytes.
- **Conclusion**: The introduction of the ADA gene into bone marrow cells at embryonic stages can potentially provide a permanent cure for SCID, making this the correct answer.

4. **Hemophilia**:
- Hemophilia is a genetic disorder that affects the blood's ability to clot, typically due to a deficiency in clotting factors. It is inherited in an X-linked recessive pattern.
- **Conclusion**: Hemophilia is not related to the ADA gene, so this option is incorrect.

**Final Answer**: The introduction of the ADA gene into bone marrow cells at embryonic stages may act as a permanent cure for **SCID (Severe Combined Immunodeficiency)**.

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