An example of molecular pharming are all, Except:

Options

A. A. Introduction of hirudin synthesissing gene in Brassica napus
B. B. Inroduction of human `alpha` - lactalbumin gene in Rosie
C. C. Introuction of gene production of a-1 antitrypsin in Tracy
D. D. Introduction of human growth hormone producing gene in common carp and gold fish

Answer

To solve the question, "An example of molecular pharming are all, Except:", we need to analyze each option provided and determine which one does not fit the criteria of molecular farming.

### Step-by-Step Solution:

1. **Understand Molecular Farming**: Molecular farming refers to the use of genetically modified plants or animals to produce pharmaceutical substances, such as proteins or hormones, for medical use.

2. **Evaluate Option A**:
- **Introduction of hirudin synthesizing gene in Brassica napus**: Hirudin is a protein derived from the leech Hirudo medicinalis, and introducing its gene into Brassica napus (a type of oilseed rape) to produce hirudin is a clear example of molecular farming.
- **Conclusion**: This option is a valid example of molecular farming.

3. **Evaluate Option B**:
- **Introduction of human alpha lactalbumin gene in Rosie (a cow)**: The alpha lactalbumin gene is responsible for producing a protein found in human milk. Introducing this gene into a cow to produce milk that mimics human milk is also an example of molecular farming.
- **Conclusion**: This option is a valid example of molecular farming.

4. **Evaluate Option C**:
- **Introduction of gene for production of alpha-1 antitrypsin in Tracy (a sheep)**: Alpha-1 antitrypsin is a human protein that can be produced in genetically modified sheep. This was successfully done in the 1990s, making it another example of molecular farming.
- **Conclusion**: This option is a valid example of molecular farming.

5. **Evaluate Option D**:
- **Introduction of human growth hormone producing gene in common carp and goldfish**: This option is problematic because the human growth hormone gene was initially introduced into bacteria (like E. coli) for production, not into fish. Thus, this does not fit the definition of molecular farming as it does not involve the direct use of plants or animals for pharmaceutical production.
- **Conclusion**: This option is the exception and does not qualify as an example of molecular farming.

### Final Answer:
The correct answer is **Option D**: Introduction of human growth hormone producing gene in common carp and goldfish.

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