Mark the statement that is incorrect with respect to application of biotechnology:

Options

A. A. In 1997, the first transgenic cow, Rosie was introduced with a-1 antitrypsin gene
B. B. Today transgenic models exist for cancer, cystic fibrosis , rheumatoid arthritis and Alzheimers disease
C. C. Trangenic mice are being used to test the safety of the polio vaccine
D. D. GEAC is an organisation that makes decisions regarding the validity of GM research and safety of introducting GM organism for public services

Answer

To determine the incorrect statement regarding the applications of biotechnology, we will analyze each option provided in the question.

### Step-by-Step Solution:

1. **Analyze Option A**:
- The statement claims that in 1997, the first transgenic cow, Rosie, was introduced with the alpha-1 antitrypsin gene.
- **Fact Check**: Rosie was indeed the first transgenic cow, but she was introduced to produce milk enriched with human alpha-lactoalbumin, not the alpha-1 antitrypsin gene.
- **Conclusion**: This statement is incorrect.

2. **Analyze Option B**:
- This statement claims that today, transgenic models exist for cancer, cystic fibrosis, rheumatoid arthritis, and Alzheimer's disease.
- **Fact Check**: This is true; various transgenic models have been developed for these diseases to study their progression and potential treatments.
- **Conclusion**: This statement is correct.

3. **Analyze Option C**:
- The statement indicates that transgenic mice are being used to test the safety of the polio vaccine.
- **Fact Check**: This is accurate; transgenic mice are indeed used in vaccine safety testing to ensure that they are safe for human use.
- **Conclusion**: This statement is correct.

4. **Analyze Option D**:
- This statement refers to the Genetic Engineering Approval Committee (GEAC), which makes decisions regarding the validity of GM research and the safety of introducing GM organisms for public services.
- **Fact Check**: This is also true; the GEAC is responsible for overseeing GM research and ensuring public safety.
- **Conclusion**: This statement is correct.

### Final Answer:
The incorrect statement with respect to the application of biotechnology is **Option A**: "In 1997, the first transgenic cow, Rosie, was introduced with alpha-1 antitrypsin gene."

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