The pH value of gasfric juice in humna stomach is about 1.8 and in intiestine , it is about 7.8. The `pk_(a)` value of aspirin is 3.5 Aspirin will be

Options

A. Completely ionised in the small intestine and in the stomach
B. unionized in the small intestine and in the stomach
C. ionized in the samll intestine and almost unionised in the stomach
D. ionised in the stomach and almost unionised in the small intestine

Answer

To determine the ionization behavior of aspirin in the human body, we need to analyze the pH of the environments where aspirin is present and its pKa value.

### Step-by-Step Solution:

1. **Identify the pH of the environments**:
- The pH of gastric juice in the stomach is approximately 1.8 (acidic).
- The pH of intestinal juice in the small intestine is approximately 7.8 (slightly basic).

2. **Identify the pKa of aspirin**:
- The pKa value of aspirin is given as 3.5.

3. **Determine the ionization of aspirin**:
- The ionization of a weak acid (like aspirin) can be analyzed using the Henderson-Hasselbalch equation or by comparing the pH of the environment to the pKa.
- If the pH < pKa, the acid will remain mostly unionized (non-ionized).
- If the pH > pKa, the acid will ionize.

4. **Analyze the situation in the stomach**:
- In the stomach (pH 1.8), since 1.8 < 3.5, aspirin will remain mostly unionized in this acidic environment.

5. **Analyze the situation in the small intestine**:
- In the small intestine (pH 7.8), since 7.8 > 3.5, aspirin will ionize in this slightly basic environment.

6. **Conclusion**:
- Aspirin will be unionized in the stomach and ionized in the small intestine.

### Final Answer:
Aspirin will be ionized in the small intestine and almost unionized in the stomach.