Cancer is generally caused due to activation of ………..to ………….and/or inactivation of ……….

Options

A. Oncogene, tumour suppressor gene, protooncogene
B. Tumour suppressor gene, oncogene, protooncogene
C. Protooncogene, oncogene, tumour suppressor gene
D. Oncogene, protooncogene, tumour suppressor gene

Answer

To solve the question "Cancer is generally caused due to activation of ………..to ………….and/or inactivation of ……….," we will break down the terms involved and analyze the options provided.

### Step-by-Step Solution:

1. **Understanding Key Terms:**
- **Oncogene:** A gene that has the potential to cause cancer. When mutated or expressed at high levels, it can lead to uncontrolled cell growth.
- **Proto-oncogene:** A normal gene that can become an oncogene due to mutations or increased expression. It is the precursor to an oncogene.
- **Tumor Suppressor Gene:** A gene that protects a cell from one step on the path to cancer. When these genes are inactivated, the cell can grow uncontrollably, leading to cancer.

2. **Analyzing the Activation Process:**
- The question asks for what is activated to what. In the context of cancer:
- When a **proto-oncogene** is activated, it becomes an **oncogene**. This means that the first part of the answer should be "proto-oncogene" to "oncogene".

3. **Analyzing the Inactivation Process:**
- The second part of the question asks for what is inactivated. For cancer to develop, tumor suppressor genes must be inactivated. This allows for uncontrolled cell division and tumor formation.

4. **Putting It All Together:**
- Therefore, the complete answer to the question is:
- Cancer is generally caused due to activation of **proto-oncogene** to **oncogene** and/or inactivation of **tumor suppressor gene**.

5. **Final Answer:**
- The correct option is the third one: "Cancer is generally caused due to activation of proto-oncogene to oncogene and/or inactivation of tumor suppressor gene."