`alpha` -ketoglutaric acid can be converted into glutamate in the presence of

Options

A. NADPH and glutamate dehydrogenase
B. Transmiase and NADPH
C. NADP and gluatamate dehydrogenase
D. NADPH and `alpha` ketogutaric acid dehydrogenase

Answer

To solve the question of how alpha-ketoglutaric acid can be converted into glutamate, we can follow these steps:

### Step-by-Step Solution:

1. **Identify the Reaction**: The conversion of alpha-ketoglutaric acid to glutamate is known as reductive amination. This process involves the addition of an amino group to the alpha-ketoglutaric acid.

2. **Understand the Role of Enzymes**: The enzyme that catalyzes this reaction is called glutamate dehydrogenase. This enzyme facilitates the conversion of alpha-ketoglutaric acid into glutamate.

3. **Identify the Co-factors Required**: During the reductive amination process, NADPH (Nicotinamide adenine dinucleotide phosphate) acts as a reducing agent. It provides the necessary electrons for the reaction to proceed.

4. **Combine All Components**: Therefore, the complete reaction involves alpha-ketoglutaric acid reacting with ammonium ions in the presence of NADPH and the enzyme glutamate dehydrogenase to produce glutamate.

5. **Select the Correct Answer**: Based on the components involved in the conversion, the correct answer to the question is "NADPH and glutamate dehydrogenase."

### Final Answer:
The conversion of alpha-ketoglutaric acid into glutamate occurs in the presence of NADPH and glutamate dehydrogenase.

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