Haemoglobins of normal and sickle cell patient are subjected to electrophoresis. They will show

Options

A. Same mobility
B. Different mobilities
C. Hvb of patient does not move at all
D. Hbs are immobile

Answer

### Step-by-Step Solution:

1. **Understanding Electrophoresis**:
- Electrophoresis is a technique used to separate charged particles, such as proteins, in a gel or fluid under the influence of an electric field. The separation occurs based on the size and charge of the molecules.

2. **Identifying the Hemoglobins**:
- In this case, we are comparing the hemoglobin from normal individuals (normal hemoglobin) and individuals with sickle cell anemia (sickle cell hemoglobin).

3. **Structure of Hemoglobin**:
- Normal hemoglobin (HbA) consists of two alpha and two beta subunits (α2β2).
- Sickle cell hemoglobin (HbS) has a mutation in the beta subunit, where the sixth amino acid (glutamic acid) is replaced by valine.

4. **Effect of Mutation on Mobility**:
- The change in the amino acid sequence in the beta subunit of sickle cell hemoglobin affects its charge and structure.
- As a result, when subjected to electrophoresis, normal hemoglobin and sickle cell hemoglobin will migrate differently due to their distinct molecular weights and charges.

5. **Conclusion**:
- Therefore, when the hemoglobins from normal and sickle cell patients are subjected to electrophoresis, they will show different mobilities.

### Final Answer:
The hemoglobins of normal and sickle cell patients, when subjected to electrophoresis, will show **different mobilities**.

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