Lathyrism which is caused by consumption of kesri dal is a disease characterized by:

Options

A. reproductive failure, susceptibility to diabets mellitus and skeletal abnormalities
B. retardation of body growth, precocious puberty and renal dysfuntion
C. maental retardation, delay in the onset of puberty and cardiovascular abnormalties
D. gross skeletal deformation and thinning of collagen fibres and fibrils

Answer

### Step-by-Step Solution:

1. **Understanding Lathyrism**: Lathyrism is a disease caused by the consumption of certain legumes, particularly Kesari dal, which comes from the plant Lathyrus sativus.

2. **Identifying Symptoms**: The disease is characterized by several symptoms, including:
- Reproductive failure
- Skeletal abnormalities
- Growth retardation
- Cardiovascular issues
- Mental retardation
- Renal dysfunction
- Delayed onset of puberty

3. **Mechanism of Action**: The primary cause of these symptoms is linked to the effect of the toxins present in Kesari dal, which disrupt the normal cross-linking of collagen fibers in the body. Collagen is a crucial protein that provides structure and strength to connective tissues.

4. **Collagen and Its Importance**: Collagen fibers are essential for maintaining the integrity of bones, cartilage, and other connective tissues. When the cross-linking of these fibers is impaired, it leads to skeletal deformities and other associated health issues.

5. **Conclusion**: The characteristic features of Lathyrism include gross skeletal deformation and thinning of collagen fibers, which ultimately lead to various health complications.

### Final Answer:
Lathyrism, caused by the consumption of Kesari dal, is characterized by gross skeletal deformation and thinning of collagen fibers.

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