Enzyme responsible for replication of HIV in macrophages is

Options

A. RNA polymerase
B. DNA Ligase
C. DNA polymerase
D. Reverse transcriptase

Answer

To answer the question about the enzyme responsible for the replication of HIV in macrophages, we can follow these steps:

### Step-by-Step Solution:

1. **Identify the Options**: The options provided are RNA polymerase, DNA ligase, DNA polymerase, and reverse transcriptase.

2. **Understand RNA Polymerase**: RNA polymerase is an enzyme that synthesizes RNA from a DNA template during the process of transcription. It does not play a role in the replication of HIV.

3. **Understand DNA Ligase**: DNA ligase is an enzyme that joins together DNA fragments. It is involved in DNA repair and replication but does not directly replicate HIV.

4. **Understand DNA Polymerase**: DNA polymerase is responsible for synthesizing new DNA strands during DNA replication. However, it does not directly replicate HIV, which has an RNA genome.

5. **Understand Reverse Transcriptase**: Reverse transcriptase is an enzyme that synthesizes DNA from an RNA template. In the case of HIV, which has RNA as its genetic material, reverse transcriptase converts the viral RNA into DNA. This DNA can then integrate into the host cell's genome, including macrophages.

6. **Conclusion**: Since HIV's replication involves converting its RNA genome into DNA using reverse transcriptase, the correct answer to the question is reverse transcriptase.

### Final Answer:
The enzyme responsible for replication of HIV in macrophages is **reverse transcriptase**.

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