Drug that increases cardiovascular effects is

Options

A. Nicotine+Cocaine
B. Benzodiazepine+Barbiturate
C. Barbiturates + Novacaine
D. Insulin + amphetamine

Answer

To answer the question "Drug that increases cardiovascular effects is", we will analyze the provided options step by step.

### Step 1: Analyze the first option - Nicotine plus Cocaine
- **Nicotine**: This drug is known to stimulate the release of neurotransmitters, particularly dopamine, which can lead to increased heart rate and blood pressure.
- **Cocaine**: This stimulant also increases dopamine levels and has similar cardiovascular effects, including increased heart rate and blood pressure.
- **Conclusion**: Both nicotine and cocaine are stimulants that enhance cardiovascular activity.

### Step 2: Analyze the second option - Benzodiazepine plus Barbiturate
- **Benzodiazepines**: These are central nervous system (CNS) depressants that can reduce anxiety and induce sedation.
- **Barbiturates**: Similar to benzodiazepines, barbiturates are also CNS depressants.
- **Conclusion**: Both of these drugs would likely decrease cardiovascular effects due to their depressant nature.

### Step 3: Analyze the third option - Barbiturates plus Novocaine
- **Barbiturates**: As mentioned, these are CNS depressants.
- **Novocaine**: This is a local anesthetic that stabilizes neuronal membranes and prevents nerve impulse transmission.
- **Conclusion**: Both drugs do not enhance cardiovascular effects; rather, they may reduce them.

### Step 4: Analyze the fourth option - Insulin plus Amphetamine
- **Insulin**: This hormone lowers blood glucose levels and does not have a direct stimulating effect on the cardiovascular system.
- **Amphetamine**: This drug is a stimulant that can increase heart rate and blood pressure, but it also inhibits insulin activity.
- **Conclusion**: While amphetamine can increase cardiovascular effects, insulin does not, making this combination less effective in enhancing cardiovascular effects.

### Final Conclusion
After analyzing all options, the only combination that clearly increases cardiovascular effects is **Nicotine plus Cocaine**.

### Answer: Nicotine plus Cocaine

---