What are the various causes of human genetic disorders?

Explanation

The various causes of human genetic disorders are as follows
(i) Mendelian disorders are caused due to the alteration or mutation in as single gene.
(ii) Chromosomal disorders are caused due to the excess, absence or abnormal arrangement of one or more chromosomes.
(iii) Failure of segregation of chromatids during cell division also results in the gain or loss of a chromosome called aneuploidy.
(iv) Failure of cytokinesis after telophase stage results in an increase in a whole set of chromosomes called polyploidy.