Inhibition of succinate dehydrogenase by malonate is the example of -

Options

A. Noncompetitive inhibition
B. Competitive inhibition
C. Allosteric inhibition
D. Negative feedback

Answer

### Step-by-Step Solution

1. **Understanding the Components**:
- Identify the enzyme involved: **Succinate dehydrogenase** (E).
- Identify the inhibitor: **Malonate** (I).

2. **Types of Inhibition**:
- There are different types of enzyme inhibition: non-competitive, competitive, allosteric, and negative feedback inhibition.

3. **Evaluating Non-Competitive Inhibition**:
- Non-competitive inhibition occurs when an inhibitor binds to a site other than the active site, which does not apply in this case as malonate does not bind elsewhere.

4. **Evaluating Competitive Inhibition**:
- Competitive inhibition occurs when the inhibitor (malonate) competes with the substrate (succinate) for the active site of the enzyme (succinate dehydrogenase).
- Since malonate has a similar structure to succinate, it can bind to the active site, preventing succinate from binding.

5. **Conclusion**:
- Since malonate competes with succinate for the active site of succinate dehydrogenase, the type of inhibition exhibited here is **competitive inhibition**.

### Final Answer
Inhibition of succinate dehydrogenase by malonate is an example of **competitive inhibition**.

---