When apoenzyme is separated from its metal component its activity is -

Options

A. Decreased
B. Increased
C. Lost
D. Not effected

Answer

To answer the question "When apoenzyme is separated from its metal component its activity is -", we need to understand the relationship between apoenzymes and their cofactors, particularly metal activators.

### Step-by-Step Solution:

1. **Define Apoenzyme**: An apoenzyme is the protein part of an enzyme that requires a cofactor to be active. It is inactive on its own without the cofactor.

2. **Understand Cofactors**: Cofactors are non-protein components that assist in enzyme activity. They can be metal ions (like zinc, magnesium, etc.) or organic molecules (coenzymes).

3. **Role of Metal Activators**: Metal activators are a type of cofactor that are essential for the activity of certain enzymes. They help in stabilizing the enzyme structure or participate in the catalytic process.

4. **Separation of Apoenzyme from Metal Component**: When the apoenzyme is separated from its metal activator, it loses its functional ability to catalyze reactions. This is because the metal component is crucial for maintaining the proper structure and function of the enzyme.

5. **Conclusion**: Therefore, when the apoenzyme is separated from its metal component, its activity is lost. The correct answer to the question is that the activity is "lost".

### Final Answer:
The activity of the apoenzyme when separated from its metal component is **lost**.