Which of the following does not occur during mitotic prophase?

Options

A. Disappearance of the nuclear envelope
B. Chromosome condensation
C. Migration of centrioles towards the cell poles
D. Synapsis of homologous chromosomes

Answer

To determine which of the following does not occur during mitotic prophase, we need to understand the key events that take place during this phase of mitosis.

### Step-by-Step Solution:

1. **Understanding Mitosis**: Mitosis is the process of cell division that results in two genetically identical daughter cells. It consists of several phases: prophase, metaphase, anaphase, and telophase.

2. **Identifying Prophase Events**: During mitotic prophase, several important events occur:
- Chromatin condenses into visible chromosomes.
- Each chromosome consists of two sister chromatids joined at the centromere.
- The nuclear envelope begins to break down.
- The mitotic spindle begins to form from the centrosomes.

3. **Differentiating from Meiosis**: It is crucial to note that certain processes are specific to meiosis, such as:
- **Synapsis of Homologous Chromosomes**: This is the pairing of homologous chromosomes that occurs during meiosis, specifically in prophase I. This process does not occur in mitosis.

4. **Conclusion**: Since synapsis of homologous chromosomes does not occur during mitotic prophase, the correct answer to the question is that this event is not part of mitotic prophase.

### Final Answer:
The event that does not occur during mitotic prophase is the synapsis of homologous chromosomes.

---