The major events of mitotic prophase include cell of the following except-

Options

A. Condensation of chromosomal materials to form compact chromosomes.
B. Nuclear membrane breakdown and nucleolar dis saggregation
C. DNA replication
D. None of these

Answer

To answer the question regarding the major events of mitotic prophase, we need to analyze the events that occur during this stage of the cell cycle. Here’s a step-by-step breakdown:

### Step-by-Step Solution:

1. **Understand the Cell Cycle**: The cell cycle consists of interphase and the mitotic phase (M phase). Interphase is further divided into G1, S, and G2 phases. The M phase includes prophase, metaphase, anaphase, and telophase.

2. **Identify the Stages of Mitosis**: During the M phase, the cell undergoes mitosis, which is the process of cell division. Prophase is the first stage of mitosis.

3. **List Major Events of Prophase**:
- **Chromosome Condensation**: During prophase, chromatin condenses into visible chromosomes.
- **Nuclear Envelope Breakdown**: The nuclear membrane disintegrates, allowing the chromosomes to move freely in the cytoplasm.
- **Formation of Spindle Fibers**: The mitotic spindle begins to form from the centrosomes.

4. **Identify Events Not Occurring in Prophase**:
- **DNA Replication**: This event does not occur during prophase. DNA replication takes place during the S phase of interphase, prior to mitosis.

5. **Conclusion**: The major events of mitotic prophase include chromosome condensation, nuclear envelope breakdown, and spindle formation, but do not include DNA replication.

### Final Answer:
The major events of mitotic prophase include all of the following except **DNA replication**.