Microtubules that form the mitotic spindle tend to originate from ____ and terminate in _____

Options

A. Centromeres, telomeres
B. Centrioles, telomere
C. Centrioles, kinetochores
D. The nuclear envelope, Kinetochore

Answer

### Step-by-Step Solution:

1. **Understanding the Components**: In the context of cell division, particularly during mitosis, microtubules play a crucial role in forming the mitotic spindle. The mitotic spindle is essential for the separation of chromosomes.

2. **Origin of Microtubules**: Microtubules that form the mitotic spindle originate from structures called centrioles. Centrioles are cylindrical organelles found in pairs, and they are located near the nucleus of the cell.

3. **Termination of Microtubules**: The microtubules extend from the centrioles and attach to specific regions on the chromosomes known as kinetochores. The kinetochore is a proteinaceous disk that forms on the centromere of each chromosome during cell division.

4. **Conclusion**: Therefore, the microtubules that form the mitotic spindle originate from **centrioles** and terminate in **kinetochores**.

### Final Answer:
Microtubules that form the mitotic spindle tend to originate from **centrioles** and terminate in **kinetochores**.

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