Restorage of nucleocytoplasmic ratio is performed in :-

Options

A. ` G_(1)` phase
B. `G_(2)` phase
C. S phase
D. M phase

Answer

To solve the question regarding the restoration of the nucleocytoplasmic ratio, we can break down the process step by step.

### Step-by-Step Solution:

1. **Understanding Nucleocytoplasmic Ratio**: The nucleocytoplasmic ratio refers to the ratio of the nucleus size to the cytoplasm size in a cell. This ratio is crucial for proper cell function and regulation.

2. **Cell Cycle Phases**: The cell cycle consists of several phases: G1 (Gap 1), S (Synthesis), G2 (Gap 2), and M (Mitosis). During these phases, the cell prepares for division and duplicates its DNA and organelles.

3. **DNA Duplication in the S Phase**: During the S phase, the DNA within the nucleus is replicated, leading to a doubling of the genetic material. This means that the amount of DNA in the nucleus increases.

4. **Organelles Duplication**: Along with DNA, many organelles within the cytoplasm also replicate during the cell cycle, particularly during the G2 phase.

5. **Karyokinesis and Cytokinesis**: Karyokinesis is the process of nuclear division that occurs during the M phase (Mitosis). This phase ensures that the duplicated DNA is evenly distributed into two daughter nuclei.

6. **Restoration of Nucleocytoplasmic Ratio**: After karyokinesis, the cell undergoes cytokinesis, where the cytoplasm divides, resulting in two separate cells. This division restores the nucleocytoplasmic ratio by ensuring that each daughter cell has an appropriate amount of cytoplasm relative to its nucleus.

7. **Conclusion**: Therefore, the restoration of the nucleocytoplasmic ratio is performed during the M phase of the cell cycle, specifically through the processes of karyokinesis and cytokinesis.

### Final Answer:
The restoration of the nucleocytoplasmic ratio is performed in the M phase of the cell cycle.

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