During the energy-priming portion of glycolysis, the phosphates from ATP molecules are -

Options

A. Added to first and 6th carbon
B. Added to 1st and 4th carbon
C. Wasted as an energy investment
D. Used to make lactate

Answer

### Step-by-Step Solution:

1. **Understanding Glycolysis**: Glycolysis is a metabolic pathway that converts glucose into pyruvate, producing ATP and NADH in the process. The pathway can be divided into two phases: the energy investment phase and the energy payoff phase.

2. **Energy Priming Phase**: The energy-priming portion of glycolysis refers to the initial steps where ATP is used to add phosphate groups to glucose. This phase requires energy input, hence the term "energy investment."

3. **Identifying Key Enzymes**:
- The first step involves the enzyme **hexokinase**, which catalyzes the conversion of glucose to glucose-6-phosphate. In this reaction, a phosphate group from ATP is transferred to glucose.
- The second step involves the enzyme **phosphofructokinase**, which catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Again, a phosphate group from ATP is used in this reaction.

4. **Phosphate Addition**:
- In the first step, the phosphate from ATP is added to the **6th carbon** of glucose, resulting in glucose-6-phosphate.
- In the second step, the phosphate from ATP is added to the **1st carbon** of fructose, resulting in fructose-1,6-bisphosphate.

5. **Evaluating Options**:
- **Option 1**: Added to the first and sixth carbon (Correct, as explained above).
- **Option 2**: Added to the first and fourth carbon (Incorrect, as the fourth carbon is not involved).
- **Option 3**: Wasted as energy investment (Incorrect, as the phosphates are utilized).
- **Option 4**: Used to make lactate (Incorrect, as lactate production is not part of the energy-priming phase).

6. **Conclusion**: The correct answer is **Option 1**, where the phosphates from ATP molecules are added to the first and sixth carbons of glucose and fructose, respectively.