Kreb's cycle is considered as amphibolic because of facts as follows -

Options

A. The intermediates of the cycle are used as precursors in the biosynthesis of many compounds
B. It is sole process to produce ATP
C. It is the oxidation of acetyl CoA in `CO_(2)andh_(2)O`
D. a and c

Answer

### Step-by-Step Text Solution:

1. **Understanding the Kreb's Cycle**: The Kreb's cycle, also known as the citric acid cycle or TCA cycle, is a crucial metabolic pathway that plays a significant role in cellular respiration. It is termed "amphibolic" because it involves both catabolic and anabolic processes.

2. **Catabolic Reactions**: In the Kreb's cycle, catabolic reactions break down complex molecules into simpler ones. For instance, the cycle oxidizes acetyl-CoA (derived from carbohydrates, fats, and proteins) to produce carbon dioxide (CO2) and water (H2O), releasing energy in the form of ATP.

3. **Anabolic Reactions**: Conversely, the Kreb's cycle also provides intermediates that serve as precursors for biosynthetic pathways. These intermediates can be used to synthesize amino acids, nucleotides, and other essential biomolecules, demonstrating the anabolic aspect of the cycle.

4. **Intermediates of the Kreb's Cycle**: The cycle produces several key intermediates, including citric acid (6 carbons), alpha-ketoglutarate (5 carbons), succinate (4 carbons), fumarate (4 carbons), and oxaloacetate (4 carbons). These intermediates can be utilized in various biosynthetic pathways, highlighting the cycle's role in both energy production and the synthesis of complex molecules.

5. **Conclusion**: Thus, the Kreb's cycle is considered amphibolic because it encompasses both catabolic reactions (energy production) and anabolic reactions (biosynthesis of complex molecules). It serves as a vital link between the breakdown of nutrients and the synthesis of necessary cellular components.