How many oxidation, decarboxylation and substrate level phosphorylation occurs respectively during complete oxidation of two pyruvate molecule :-

Options

A. 3, 5, 1
B. 6, 10, 2
C. 10, 6, 2
D. 5, 3,1

Answer

To determine the number of oxidation, decarboxylation, and substrate-level phosphorylation that occurs during the complete oxidation of two pyruvate molecules, we can break down the process step by step.

### Step-by-Step Solution:

1. **Understanding Pyruvate Oxidation**:
- Each pyruvate molecule (3 carbon) is converted into acetyl CoA (2 carbon) through a process called decarboxylation, where one carbon atom is removed in the form of carbon dioxide (CO2).

2. **Decarboxylation**:
- For each pyruvate, one decarboxylation occurs. Since we have two pyruvate molecules, the total number of decarboxylation reactions is:
\[ 2 \text{ (pyruvate)} \times 1 \text{ (decarboxylation per pyruvate)} = 2 \text{ decarboxylations} \]

3. **Oxidation**:
- During the conversion of pyruvate to acetyl CoA, there is also an oxidation reaction where hydrogen atoms are removed. This process occurs once for each pyruvate molecule. Additionally, during the TCA cycle (Krebs cycle), further oxidation occurs.
- The oxidation steps can be summarized as follows:
- 1 oxidation during the conversion of each pyruvate to acetyl CoA (2 total for 2 pyruvate).
- In the TCA cycle, there are 5 oxidation reactions that occur for each acetyl CoA.
- Therefore, for 2 acetyl CoA, the total oxidation reactions are:
\[ 2 \text{ (from pyruvate to acetyl CoA)} + 5 \text{ (in TCA cycle)} \times 2 \text{ (for 2 acetyl CoA)} = 2 + 10 = 12 \text{ oxidations} \]

4. **Substrate-Level Phosphorylation**:
- In the TCA cycle, one GTP (which is equivalent to ATP) is produced for each acetyl CoA. Since we have 2 acetyl CoA, the total substrate-level phosphorylation is:
\[ 2 \text{ (acetyl CoA)} \times 1 \text{ (GTP per acetyl CoA)} = 2 \text{ substrate-level phosphorylations} \]

5. **Final Count**:
- Now, we can summarize the results:
- Oxidation: 12
- Decarboxylation: 2
- Substrate-level Phosphorylation: 2

### Conclusion:
The total counts for the complete oxidation of two pyruvate molecules are:
- **Oxidation**: 12
- **Decarboxylation**: 2
- **Substrate-Level Phosphorylation**: 2

### Final Answer:
**12, 2, 2**

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