Cells responsible for release of Castle's intrinsic factor are

Options

A. Peptic cells
B. Paneth cells
C. Parietal cells
D. Chief cells

Answer

To solve the question regarding which cells are responsible for the release of Castle's intrinsic factor, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Question**: We need to identify the specific type of cells that release Castle's intrinsic factor.

2. **Review the Options**: The options provided are:
- A) Peptic cells
- B) Paneth cells
- C) Parietal cells
- D) Chief cells

3. **Recall the Function of Each Cell Type**:
- **Peptic Cells**: These cells are primarily responsible for producing pepsinogen, an inactive enzyme that is converted to pepsin in the acidic environment of the stomach.
- **Paneth Cells**: These cells are found in the intestinal crypts and are involved in the secretion of antimicrobial substances.
- **Parietal Cells**: These cells are located in the gastric glands of the stomach and are responsible for producing hydrochloric acid (HCl) and intrinsic factor.
- **Chief Cells**: These cells are also located in the gastric glands and are responsible for producing pepsinogen.

4. **Identify the Correct Cell Type**: Among the options, parietal cells are known to secrete Castle's intrinsic factor, which is essential for the absorption of vitamin B12 in the intestines.

5. **Conclusion**: Therefore, the correct answer is **C) Parietal cells**.

### Final Answer:
The cells responsible for the release of Castle's intrinsic factor are **Parietal cells**.