Which of the following events is not associated with ovulation in human female?

Options

A. Release of secondary cocyte
B. LH surge
C. Decrease in estradiol
D. Full development of Graafian follicle

Answer

To solve the question "Which of the following events is not associated with ovulation in human female?", we will analyze each option provided and determine whether it is associated with the ovulation process.

### Step-by-step Solution:

1. **Understanding Ovulation**:
- Ovulation is the process where a mature ovarian follicle releases a secondary oocyte (egg) into the fallopian tube. This typically occurs around the 14th day of the menstrual cycle in human females.

2. **Identifying the Ovulatory Phase**:
- The menstrual cycle in human females lasts about 28 days, and the ovulatory phase is the shortest phase, occurring around day 14.

3. **Analyzing Each Option**:
- **Option 1: Release of secondary oocyte**: This is a key event of ovulation. During ovulation, the mature Graafian follicle releases the secondary oocyte. Therefore, this option is associated with ovulation.

- **Option 2: Luteinizing hormone (LH) surge**: The LH surge is crucial for triggering ovulation. It peaks around day 14, leading to the release of the secondary oocyte. Thus, this option is also associated with ovulation.

- **Option 3: Decrease in estradiol**: Estradiol is a form of estrogen produced by the developing follicles. During the lead-up to ovulation, estradiol levels actually increase, peaking just before the LH surge. Therefore, a decrease in estradiol is not associated with ovulation.

- **Option 4: Full development of Graafian follicle**: The full development of the Graafian follicle is necessary for ovulation to occur, as it is the structure that releases the secondary oocyte. Hence, this option is associated with ovulation.

4. **Conclusion**:
- Based on the analysis, the event that is **not associated** with ovulation is **Option 3: Decrease in estradiol**.

### Final Answer:
**Option 3: Decrease in estradiol** is not associated with ovulation in human females.

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