Which of the following combinations causes damage to gastric mucosa?

Options

A. alcohol & valium
B. alcohol & barbiturate
C. alcohol & aspirin
D. alcohol & hashish

Answer

To determine which combinations cause damage to the gastric mucosa, we need to analyze the factors that are known to affect gastric health. Here’s a step-by-step solution:

### Step 1: Identify the factors that can damage the gastric mucosa
- The gastric mucosa can be damaged by various substances, including alcohol, non-steroidal anti-inflammatory drugs (NSAIDs), and certain bacteria (like Helicobacter pylori).

### Step 2: Understand the role of alcohol
- Alcohol consumption is known to increase gastric acid secretion. Excessive acid can erode the gastric mucosa, leading to inflammation and ulcers.

### Step 3: Consider the impact of NSAIDs
- Non-steroidal anti-inflammatory drugs (NSAIDs) can inhibit the production of protective mucus in the stomach lining, making it more susceptible to damage from gastric acid.

### Step 4: Evaluate the combination of factors
- A combination of alcohol and NSAIDs is particularly harmful as both increase gastric acid secretion and reduce the protective mechanisms of the gastric mucosa.

### Step 5: Conclusion
- Therefore, the combination of alcohol and NSAIDs is likely to cause significant damage to the gastric mucosa.

### Final Answer
The combination of alcohol and NSAIDs causes damage to the gastric mucosa.

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