Deliberate alteration of genome for treatment of disease is called-

Options

A. Transformation rescue
B. Imprinting
C. Exon shuffle
D. Gene therapy

Answer

**Step-by-Step Text Solution:**

1. **Understanding the Question**: The question asks for the term that describes the deliberate alteration of an organism's genome for the purpose of treating diseases.

2. **Defining Genome Alteration**: Genome alteration refers to the intentional modification of the genetic material (DNA) of an organism. This can involve adding, removing, or altering specific genes.

3. **Purpose of Genome Alteration**: The primary goal of altering the genome in this context is to treat or cure diseases. By modifying genes, it is possible to correct genetic defects or enhance the body’s ability to fight diseases.

4. **Identifying the Technique**: The technique used for this purpose is known as **gene therapy**. Gene therapy involves the introduction, removal, or alteration of genetic material within a person's cells to treat disease.

5. **Historical Example**: One of the first successful applications of gene therapy was for treating Severe Combined Immunodeficiency (SCID) caused by a deficiency in the adenosine deaminase (ADA) enzyme. This example illustrates how gene therapy can address specific genetic disorders.

6. **Conclusion**: Therefore, the deliberate alteration of the genome for the treatment of disease is called **gene therapy**.

**Final Answer**: Gene therapy

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