Which one of the following present in normal cells, when activated under certain conditions, could lead to Oncogenic transformation of the cells.

Options

A. Viral oncogenes
B. Cellular oncogenes
C. Proto oncogenes
D. Both (b) and (c)

Answer

To solve the question regarding which component present in normal cells, when activated under certain conditions, could lead to oncogenic transformation, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Oncogenes**: Oncogenes are genes that have the potential to cause cancer. They are typically derived from normal genes called proto-oncogenes, which are involved in normal cell growth and division.

2. **Identifying the Options**: The question presents several options, including viral oncogenes, cellular oncogenes, and proto-oncogenes. We need to analyze each option to determine which one fits the criteria of being present in normal cells.

3. **Evaluating Viral Oncogenes**: Viral oncogenes are associated with viruses that can induce cancer. Since these are not naturally occurring in normal cells but are introduced by external agents (viruses), they do not fit the criteria.

4. **Evaluating Cellular Oncogenes**: Cellular oncogenes can arise from mutations in proto-oncogenes due to various factors such as UV radiation or chemical exposure. These mutations can lead to uncontrolled cell division, resulting in cancer. They are indeed present in normal cells before activation.

5. **Evaluating Proto-Oncogenes**: Proto-oncogenes are normal genes that can become oncogenes due to mutations or increased expression. They are present in normal cells and can lead to oncogenic transformation when activated under certain conditions.

6. **Conclusion**: Since both cellular oncogenes and proto-oncogenes are present in normal cells and can lead to oncogenic transformation when activated, the correct answer is both B (cellular oncogenes) and C (proto-oncogenes).

### Final Answer:
Both B and C (Cellular oncogenes and Proto-oncogenes) are present in normal cells and can lead to oncogenic transformation when activated.