Which of the following cloning tools is not an example of plasmid cloning vector?

Options

A. PBR 322
B. pUC 19
C. pBin 19
D. M13

Answer

To determine which of the following cloning tools is not an example of a plasmid cloning vector, we will analyze each option provided.

### Step-by-Step Solution:

1. **Understand Plasmid Cloning Vectors**: Plasmid cloning vectors are small, circular DNA molecules that can replicate independently of chromosomal DNA within a bacterial cell. They are commonly used in genetic engineering to clone DNA fragments.

2. **Evaluate the Options**:
- **PBR322**: This is a well-known plasmid cloning vector. It contains antibiotic resistance genes, which allow for the selection of transformed cells. Therefore, PBR322 is an example of a plasmid cloning vector.

- **PUC19**: Another common plasmid cloning vector. It is designed for high copy number and contains an antibiotic resistance gene. Thus, PUC19 is also a plasmid cloning vector.

- **Pbin19**: This is a binary vector used in plant transformation. It is derived from plasmids and includes antibiotic resistance genes. Hence, Pbin19 is a plasmid cloning vector as well.

- **M13**: Unlike the others, M13 is a filamentous bacteriophage and not a plasmid. It is used for cloning but does not have the characteristics of a plasmid cloning vector, such as the presence of antibiotic resistance genes.

3. **Conclusion**: Based on the analysis, M13 is the only option that does not qualify as a plasmid cloning vector. Therefore, the answer is M13.

### Final Answer:
The cloning tool that is not an example of a plasmid cloning vector is **M13**.