To solve the question regarding which cell organelles are involved in the manufacturing of various substances, we will analyze each option provided:
### Step-by-Step Solution:
1. **Understanding the Role of Organelles**:
- We need to identify which organelles are primarily involved in the synthesis or manufacturing of substances within the cell.
2. **Evaluating Option (a)**: Lysosome, Vacuole, Ribosome
- **Lysosome**: Primarily involved in digestion and waste removal, not manufacturing.
- **Vacuole**: Mainly serves as storage for substances, not directly involved in manufacturing.
- **Ribosome**: Yes, involved in protein synthesis.
- **Conclusion**: This option is incorrect as lysosomes and vacuoles do not manufacture substances.
3. **Evaluating Option (b)**: Ribosomes, RER, SER
- **Ribosomes**: Yes, they are the site of protein synthesis.
- **Rough Endoplasmic Reticulum (RER)**: Ribosomes are attached to RER, and it is involved in the synthesis of proteins and enzymes.
- **Smooth Endoplasmic Reticulum (SER)**: Involved in the synthesis of lipids and fats.
- **Conclusion**: This option is correct as all three organelles are involved in the manufacturing of various substances.
4. **Evaluating Option (c)**: Vacuole, RER, SER
- **Vacuole**: Again, primarily for storage, not manufacturing.
- **RER**: Yes, involved in protein synthesis.
- **SER**: Yes, involved in lipid synthesis.
- **Conclusion**: This option is incorrect due to the presence of vacuole.
5. **Evaluating Option (d)**: SER, Ribosome, Centriole
- **SER**: Yes, involved in lipid synthesis.
- **Ribosome**: Yes, involved in protein synthesis.
- **Centriole**: Primarily involved in cell division, not manufacturing.
- **Conclusion**: This option is incorrect due to the presence of centriole.
### Final Answer:
The correct answer is **(b) Ribosomes, RER, SER**.
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