To be evolution of successful, a mutation must occur in

Options

A. Germplasm DNA
B. Somatoplasm DNA
C. RNA
D. Cytoplasm

Answer

To determine where a successful mutation must occur for evolution to take place, we need to analyze the options provided and understand the nature of mutations.

### Step-by-Step Solution:

1. **Understanding Mutation**:
- A mutation is defined as any change in the nucleotide sequence of an organism's DNA. This change can be small or large and can occur randomly.

2. **Types of Cells**:
- Mutations can occur in two main types of cells: somatic cells and germ cells.
- **Somatic Cells**: These are all the body cells except the reproductive (germ) cells. Mutations in somatic cells do not get passed on to the next generation.
- **Germ Cells**: These are the reproductive cells (sperm and eggs). Mutations in these cells can be passed on to the next generation.

3. **Successful Mutation**:
- For a mutation to be considered "successful" in terms of evolution, it must be able to be inherited by the next generation. This means it must occur in the germ cells (germplasm DNA).

4. **Evaluating the Options**:
- **Germplasm DNA**: This is the correct answer because mutations here can be passed on to offspring.
- **Somatoplasm DNA**: Mutations here do not get transferred to the next generation, making this option incorrect.
- **RNA**: While RNA can undergo mutations, these mutations do not directly affect the genetic inheritance, so this option is irrelevant.
- **Cytoplasm**: Mutations do not occur in the cytoplasm in a way that affects genetic inheritance, making this option incorrect as well.

5. **Conclusion**:
- The correct answer is **Germplasm DNA** because successful mutations that contribute to evolution must occur in the germ cells to be passed on to future generations.

### Final Answer:
**Germplasm DNA**